Clinical profile of immune thrombocytopenic purpua and outcome at 6 months: a South Indian observational study


  • Srinivasan Thiagarajan Department of Pediatrics, Government Medical College, Kottayam, Kerala, India
  • Omana S. Department of Pediatrics, Government Medical College, Kottayam, Kerala, India



Immune thrombocytopenic purpura, Outcome of ITP, Profile of ITP, Spectrum of ITP


Background: Immune thrombocytopenia studies in South India is very limited. This study was carried out with an aim to find the clinical spectrum of immune thrombocytopenia and outcome of this disorder affecting the children of central Kerala and to assess whether the clinical spectrum and outcome of this disorder differs from the western population.

Methods: All newly diagnosed children of primary immune thrombocytopenia admitted in Paediatric ward from November 2012 to November 2013 were included in this study. Children with secondary causes of thrombocytopenia were excluded from the study population. Clinical profile and outcome at six months were studied. Children achieving complete response (platelet count >100 × 109/L and absence of bleeding) at six months was compared on the basis of severity of thrombocytopenia at presentation.

Results: Thirty children were studied. The common age group affected was ranging from two to six years. The incidence of intracranial bleed was 6.6% and mortality 3.3%. 75.8 % of patients attained complete response and 17.2% of patients had response at six months. No patients ended up in hematological malignancy in follow up.

Conclusions: Majority of patients with ITP does not require any intervention and only minor proportion of children progress to chronic immune thrombocytopenic purpura. Clinical spectrum and outcome of this condition does not differ from western studies. More research with larger sample size is required to study the incidence and outcome in Indian population.


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