Incidence and outcome of neonatal seizures at a tertiary care hospital


  • Abdul Naseer Abdul Bari Department of Pediatrics, Rural Hospital and Trauma Care Centre, Naigaon, Nanded, Maharashtra, India
  • Habib G. Pathan Department of Pediatrics, Malla Reddy Medical College for Women, Quthbullapur, Hyderabad, Telangana, India
  • Prashant R. Kokiwar Department of Community Medicine, Malla Reddy Institute of Medical Sciences, Suraram, Hyderabad, Telangana, India



Birth asphyxia, complications, Neonatal seizures, Preterm


Background: Seizures are associated with poor neuro developmental outcome if not diagnosed early and treated properly. During newborn period, seizures indicate underlying neurological disease. Neonatal seizures lead to increased morbidity and mortality usually found in neonatal intensive care unit. The objective of this study was to evaluate incidence and outcome of neonatal seizures.

Methods: Present study was hospital based prospective study conducted among 117 neonates of 0-28 days of age at a tertiary care hospital for a period of one year. The data like history, clinical examination and investigation findings was recorded in the pre-designed, pre-tested, semi structured questionnaire.

Results: The incidence of neonatal seizures was higher in male neonates. Subtle types of seizures were the commonest type of seizures. In term neonates, the birth asphyxia was the most common cause of neonatal seizures. The incidence of intra-ventricular hemorrhage (IVH) was significantly higher in preterm than term neonates. Out of biochemical abnormalities, the hypocalcemia was the most common cause of the neonatal seizures. Common causes of neonatal deaths in our center were severe birth asphyxia, intra-ventricular hemorrhage (IVH), septicemia and meningitis.

Conclusions: Most of the causes of neonatal seizures are preventable by good perinatal care and early interventions while metabolic seizures need a sharp vigilance and early suspicion. 


Volpe JJ. Neonatal Seizures. In: Volpe JJ, editor. Neurology of the new-born. 4th ed. Philadelphia: WB Saunders. 2001:178-216.

Scher MS. Controversies regarding the neonatal seizures recognition. Epileptic Disord 2002;4(2):139-58.

Mizrahi EM. Neonatal seizures and neonatal epileptic syndromes. Neurologic Clinics. 2001;19(2):427-56.

David P, Daryl C, Vivo D. The Nervous System. In: Rudolph Colin D. Abraham D. Rudolph, Margaret K. Hostellter, editors. 21st ed. New York: McGraw Hills; 2002:2267.

Mizrahi EP, Kellway P. Characterization and classification of neonatal Seizures. Neurol. 1987;37:1837-44.

Painter MJ. Neonatal Seizures. In: Swaiman KF, editor. Principle and practice of pediatric neurology, 2nd ed. Missouri: Mosby; 1994:555-560.

Sandhu R, Thakur P, Kesavamurthy SR. A clinical study of Seizures in Neonate. In: Manual abstracts of Pedicon. National conference of Indian Academy of Pediatrics. Mumbai: IAP. 2003;Neo/52:203-4.

Grover N. Biochemical abnormalities in neonatal seizures. In: Manual abstracts of Pedicon. National conference of Indian Academy of Pediatrics. Mumbai: IAP. 2003;Neo/10:175.

Holden KR, Mellitus ED, Freemann JM. Neonatal seizures: correlation of prenatal and perinatal events with outcome. Pediatr. 1982;70(2):165-76.

Powell C, Painter MJ, Pipeger CE. Primidone therapy in refractory seizures. J Pediatr 1983;105:651-4.

Legido A, Clancy RR, Berman PH. Neurologic outcome after electroencephalographically proven neonatal seizures. Pediatr. 1991;88(3):583-96.

Kumar A, Gupta V, Kacchawaha S. A study of biochemical abnormalities in Neonatal seizures. Indian J Pediatr. 1995;52:424-7.

Ross AL, Lombroso C. Neonatal seizure states: a study of clinical, pathological and electrographic features in 137 full term babies with a long term follow up. Pediatr. 1970:45(3):404-25.

Soni A, Sabarawal RK, Amita K. Clinical profile of Seizures in neonatal intensive care unit. In Manual abstracts of XXIII Annual Convention of National Neonatology Forum; 2003;43:109-10.

Errikscon M, Zelterstrom R. Neonatal Convulsion, Incidence and causes in Stockholm area. Acta Pediatric Scand. 1979;68:807-11.

Taksande AM, Vilhekar K, Jain M. Clinico- biochemical profile of neonatal seizures. Indian J Pediatr. 1995;52:424-7.

Ronen GM, Penney S, Andrews W. The epidemiology of clinical neonatal seizures in Newfoundland: A population-based study. J Pediatr. 1999;134:71-5.






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