Neonatal dengue


  • Jessy Thomas Department of Pediatrics, Lisie Hospital, Kochi, Kerala, India
  • Priya Thomas Department of Pediatrics, Lisie Hospital, Kochi, Kerala, India
  • Chinnu Reeba George Department of Pediatrics, Lisie Hospital, Kochi, Kerala, India



Dengue, Neonate, Platelet count, Perinatal transmission


Dengue infection is possible in all three trimesters of pregnancy. Dengue during pregnancy is associated with several neonatal complications such as perinatal death, miscarriage, low birth weight and preterm delivery. This is a case report of perinatal transmission of dengue in a baby who was born by an emergency caesarean section. The female baby was diagnosed with dengue fever as her dengue NS1 and ELISA tests were positive like her mother. Early recognition of congenital dengue will significantly reduce maternal and infant mortality. Proper management and supportive treatment is required for thrombocytopenia and hemorrhagic manifestations in dengue fever.



Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496:504-7.

Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG, et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Negl Trop Dis. 2012;6:e1760.

Barthel A, Gourinat AC, Cazorla C, Joubert C, Dupont-Rouzeyrol M, Descloux E. Breast milk as a possible route of vertical transmission of dengue virus?. CID. 2013:57(3):415-7.

Perret C, Chanthavanich P, Pengsaa K, Limkittikul K, Hutajaroen P, Bunn JE, et al. Dengue infection during pregnancy and transplacental antibody transfer in Thai mothers. J Infect. 2005;51:287-93.

Basurko C, Carles G, Youssef M, Guindi WE. Maternal and fetal consequences of dengue fever during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2009;147:29-32.

Grunnill M, Boots M. How important is vertical transmission of dengue viruses by mosquitoes (diptera: culicidae)?. J Med Entomol. 2016;53(1):1-19.

Waduge R, Malavige GN, Pradeepan M, Wijeyaratne CN, Fernando S, Seneviratne SL. Dengue infections during pregnancy: a case series from Sri Lanka and review of the literature. J Clin Virol. 2006;37:27-33.

Carroll ID, Toovey S, Gompel VA. Dengue fever and pregnancy: a review and comment. Travel Med Infect Dis. 2007;5:183-8.

Chan M, Johansson MA. The incubation periods of Dengue viruses. PLoS One. 2012;7(11):e50972.

Watanaveeradej V, Endy T, Samakoses R, Kerdpanich A, Simasathien S, Polprasert N, et al. Transplacentally transferred maternal-infant antibodies to dengue virus. Am J Trop Med Hyg. 2003;69:123-38.

Salgado DM, Rodríguez JA, Lozano LDP, Zabaleta TE. Perinatal dengue. Biomédica. 2013;33(1). Bogotá Sept. 2013.

Sirinavin S, Nuntnarumit P, Supapannachart S, Boonkasidecha S, Techasaensiri C, Yoksarn S. Vertical dengue infection: case reports and review. Pediatr Infect Dis J. 2004;23:1042-7.

Sawyer H Pouliot, Xu Xiong, Emily Harville, Pierre buckens. Maternal dengue and pregnancy outcomes: a systematic review. Obstet Gynecol Surv. 2010;65(2):107-18.

Kerdpanich A, Watanaveeradej V, Samakoses R, Chumnanvanakij SH, Chulyamitporn T, Sumeksri P, et al. Perinatal dengue infection. Southeast Asian J Trop Med Public Health. 2001;32:488-93.

Schexneider KI, Reedy EA. Thrombocytopenia in dengue fever. Curr Hematol Rep. 2005;4(2):145-8.

de Azeredo EL, Monteiro RQ, Pinto LMD. Thrombocytopenia in dengue: interrelationship between virus and the imbalance between coagulation and fibrinolysis and inflammatory mediators. Mediators Inflamm. 2015;2015:313842.