Infantile tremor syndrome

Apoorva Sree Puttagunta, Shruthi T. K., Shubha S., Rajakumar P. S.


Infantile tremor syndrome (ITS) is defined by the tetrad of pallor, developmental delay/regression, skin pigmentation, and brown scanty scalp hair. Involuntary movements in the form of tremors supervene in the natural course of the illness in a significant number of cases. The disorder is common in exclusively breast-fed infants of vegetarian mothers. Most of the children eventually recover but are frequently left with long-term cognitive and language neurodeficits. This review attempts to provide comprehensive and up-to-date information on the subject incorporating recently published studies. 


Acrodermatitis, Infantile tremor syndrome, Vitamin B12 deficiency

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