DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20174763

Infantile tremor syndrome

Apoorva Sree Puttagunta, Shruthi T. K., Shubha S., Rajakumar P. S.

Abstract


Infantile tremor syndrome (ITS) is defined by the tetrad of pallor, developmental delay/regression, skin pigmentation, and brown scanty scalp hair. Involuntary movements in the form of tremors supervene in the natural course of the illness in a significant number of cases. The disorder is common in exclusively breast-fed infants of vegetarian mothers. Most of the children eventually recover but are frequently left with long-term cognitive and language neurodeficits. This review attempts to provide comprehensive and up-to-date information on the subject incorporating recently published studies. 


Keywords


Acrodermatitis, Infantile tremor syndrome, Vitamin B12 deficiency

Full Text:

PDF

References


Dikshit AK. Nutritional dystrophy with anaemia. Indian J Child Health. 1957;6:132-6.

Gupte S, Pal M, Gupta SK ,Sangra KR .Infantile tremor syndrome [ITS] In: Gupte S, Editor. Textbook of paediatric nutrition. New Delhi:Peepee; 2006:255-265.

Gupte S. Infantile tremor syndrome. In: Gupte S, ed. The Short Textbook of Paediatrics, 10th ed. New Delhi; Jaypee Brothers. 2004:716-9.

Ghai OP, Gupta P. Infantile tremor syndrome. In: Ghai OP, Gupta P, Paul VK, eds. Ghai Essential Pediatrics 6th ed. New Delhi Dr. Ghai;2005:539-40.

Jadhav M, Webb JK, Vaishnava S, Baker SJ. Vitamin B12 deficiency in Indian infants. A clinical syndrome. Lancet. 1962;2:903-7.

Avci Z, Turul T, Aysun S, Ünal I. Involuntary movements and magnetic resonance imaging findings in infantile cobalamine (vitamin B12) deficiency. Pediatrics. 2003 Sep 1;112(3):684-6.

Jadhav M, Webb JJK, Vaishnava S. Vitamin B12 deficiency in Indian infants: a clinical syndrome Lancet. 1962;2:903-6.

Goraya JS, Kaur S. Infantile tremor syndrome: A syndrome in search of its etiology. Indian Pediatr. 2016;53:173-4.

Ratageri VH, Shepur TA, Patil MM, Hakeem MA. Scurvy in infantile tremor syndrome. Indian J Pediatr. 2005;72(10):883-4.