Clinico-etiological profile of neonatal seizures in term neonates

K. Venkataramana Reddy, C. Soren, Snigdha Jagtap, Y. Pardhasaradhi, S. Satish


Background: Neonatal seizures or neonatal convulsions are epileptic fits occurring from birth to the end of the neonatal period. Neonatal seizures are a common neurological problem with a frequency of 1.5-14/1000 neonates. Neonatal seizure is common in this part of the Telangana and there was paucity of data from this area. Identification of etiology will help in management there by reducing morbidity and mortality.

Methods: This prospective study was done in NICU of S.V.S. Medical College and Hospital, Mahabubnagar, from Jan 2016 to Jan 2017. Term neonates with clinically identifiable seizure were included in the present study. This study was approved by institutional ethical committee and written consent was obtained from parents of the studied neonates.

Results: Of 84 studied neonates, 46 were males and 38 were females. 29 neonates had seizures within first 24 hours and 22 neonates had seizures on day 2. Perinatal asphyxia was seen in 28 neonates and septicemia was seen in 21 neonates.

Conclusions: Perinatal asphyxia was the most common cause for neonatal seizures in term neonates, followed by septicaemia and metabolic disturbances. 


Neonatal seizures, Perinatal asphyxia, Septicaemia

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Panayiotopoulos CP. The Epilepsies: seizures, syndromes and management. Oxfordshire (UK): Bladon Medical Publishing; 2005. Chapter 5, Neonatal Seizures and Neonatal Syndromes. Available from:

Das D, Debbarma S. A study on clinico-biochemical profile of neonatal seizure. J Neurol Res, North America, 6, 2016. Available at: . Date accessed: 20 May. 2017.

Sabzehei MK, Basiri B, Bazmamoun H. The Etiology, Clinical Type, and Short Outcome of Seizures in Newborns Hospitalized in Besat Hospital/Hamadan/ Iran. Iran J Child Neurol. 2014;8(2):24-8.

Kang SK, Kadam SD. Neonatal seizures: impact on neurodevelopmental outcomes. Front Pediatr. 2015;23(3):101.

Kumar A, Gupta A, Talukdar B. Clinico-etiological and EEG profile of neonatal seizures. Indian J Pediatr. 2007;74(1):33-7.

Levene M. The clinical conundrum of neonatal seizures. Arch Dis Child Fetal Neonatal Ed. 2002;86(2):F75-F7.

Sahana G, Anjaiah B. Clinical profile of neonatal seizures. Int J Med Appl Sci. 2014;3(1):21-7.

Parvin R, Afmsalim, Rahman M, Chowdhury K, Sultana A, Ahmed S, et al. Neonatal seizures: correlation between clinico-etiological profile and eeg findings. Bangladesh J Child Health. 2014;38(1):19-23.

Moayedi AR, Zakeri S, Moayedi F. Neonatal seizure: etiology and type. Iranian J Child Neurol. 2008;2(2)23-6.

Ronen GM, Rosales TO, Connolly M, Anderson VE, Leppert M. Seizure characteristics in chromosome 20 benign familial neonatal convulsions. Neurology. 1993;43(7):1355-60.

Aziz A, Gattoo I, Aziz M, Rasool G. Clinical and etiological profile of neonatal seizures: a tertiary care hospital based study. Int J Res Med Sci. 2015;3:2198-2203.

Verma YS, Dutt R, Rajput N, Patil R. Predictive value of EEG for neurodevelopmental outcome in neonatal seizures. J Evol Med Dent Sci. 2013;2(29):5417-25.

Najeeb S, Qureshi AM, Anis-ur-Rehman, Ahmad F, Shah S, Khan AY, et al. Aetiology and types of neonatal seizures presenting at Ayub Teaching Hospital Abbottabad. J Ayub Med Coll Abbottabad. 2012;24(1):33-7.

Glass HC, Shellhaas RA, Wusthoff CJ, Chang T, Abend NS, Chu CJ, et al. Contemporary Profile of Seizures in Neonates: A Prospective Cohort Study. J Pediatr. 2016;174:98-103.

Malik BA, Butt MA, Shamoon M, Tehseen Z, Fatima A, Hashmat N. Seizures etiology in the newborn period. J Coll Physicians Surg Pak. 2005;15(12):786-90.

Taksande AM, Krishna V, Manish Jain, Mahaveer L. Clinico-biochemical profile of neonatal seizures. Paed Oncall J. 2005;2(10).

Sudia S, Berwal PK, Nagaraj N, Jeavaji P, Swami S, Berwal A. Clinicoetiologicalprofile and outcome of neonatal seizures. Int J Contemp Pediatr. 2015;2:389-90.