DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20174761

Epidermolysis bullosa in newborn: a case report

Gursharn Singh Narang, Ashwani Kumar, Navneet Virk, Supriya Malik

Abstract


Epidermolysis bullosa is a rare genetic connective tissue disorder. It has many genetic and symptomatic variations but all share the prominent symptom of extremely fragile skin that blisters and tears from minor trauma in the varying degrees of severity and can severely incapacitate the life of the afflicted patient. Treatment still remains a major challenge. Daily wound care, pain management and protective bandaging are the only available treatment options.


Keywords


Blistering, Epidermolysis bullosa

Full Text:

PDF

References


Ramesh BY. Epidermolysis Bullosa Simplex. J Clin Diag Res. 2010;4:3215-6.

Garg A, Levin NA, and Bernhard JD. Approach to dermatological diagnosis. In: K. Wolf, Goldsmith L, Katz S, Gilchrest B, Paller A, Leffell D. eds. Fitzpatrick’s dermatology in general medicine. 7th edition. McGraw-Hill. New York, USA; 2008:23-39.

Coulombe PA, Kerns ML, Fuchs E. Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility. J Clin Invest. 2009;119:1784-93.

Fine JG, Johnson LB, SuchindranC, Moshell A, Gedde-Dahl T Jr. In: Fine JD, Bauer EA, McGuire J, Moshell A, eds. The Epidemiology of Inherited Epidermolysis Bullosa: Findings in the US, Canadian and European study populations. Clinical, epidemiological and laboratory advances, and the findings of the national epidermolysis bullosa registry, Baltimore: John’s Hopkings university press; 1999:101-13.

Qayoom S, Masood Q, Sultan J, Hassan I, Jehangir M, Bhat YJ, et al. Epidermolysis bullosa: a series of 12 patients in Kashmir valley. Ind J Dermatol. 2010;55(3):229.

Morelli JG. Vesiculobullous disorders. In Nelson Text Book of Pediatrics. 18th edition. Philadelphia, Pennsylvania, Saunders; 2007:2685-93.

Fine JD, Eady RA, Bauer EA, Bauer JW, Bruckner-Tuderman L, Heagerty A et al. The classification of inherited Epidermolysis Bullosa: Report of the Third International Consensus Meeting on Diagnosis and Classification of Epidermolysis Bullosa. J Am Acad Dermatol. 2008;58(6):931-50.

Featherstone C. Epidermolysis bullosa: from fundamental molecular biology to clinical therapies. J Invest Dermatol. 2007;127:256-9.

Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 2004;18(2):126-31.

Sianez-Gonzalez C, Pezoa-Jares R, Salas-Alanis JC. Congential Epidermolysis Bullosa: a Review. Actas Dermo-Sifiliográficas. 2009;100(10) :842-56.