Study of clinical and radiological profile of children with neurocysticercosis

Manjunath Suresh Pandit, Jagadish Narayan Sharma, Anita Choudary, Priti Vijay


Background: To study the clinical and radiological profile of children with Neurocysticercosis Hospital based, Observational study conducted in SPMCHI, Jaipur from June 2015 to June 2016.

Methods: 50 children diagnosed of neurocysticercosis based on clinical features and findings on magnetic resonance imaging with contrast were enrolled while excluding the other common causes of granuloma.

Results: A total of 50 children completed this study. Mean age of the presentation was 8.68±2.133 (5 to 16) years, with an M: F of 0.92:1. Overall patients presented with generalized seizure in 76%, focal in 16%, headache±vomiting in 6%, focal neurodeficit in 2% and combination of symptoms in 60.5% cases. MRI brain showed a solitary lesion in 45 (90%) and multiple in 5 (10 %). At presentation lesions were vesicular in 46 %, nodular calcified in 16 %, granular nodular in 10 %, colloidal vesicular in 6% and mixed in 6%. One child presented with a starry sky appearance.

Conclusions: Neurocysticercosis usually affects young persons, youngest age of presentation 5 years, was found more common among vegetarians. Most common clinical manifestation is seizures. Single lesion is more common than multiple lesions, commonly presenting in vesicular stage. NCC should be considered first in the differential diagnosis of new-onset seizure among the children of developing countries, where taeniasis is endemic. 



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Blanton R. Cysticercosis. In: Kliegman RM, Jenson HB, Behrman RE, Stanton BF, editors. Nelson Textbook of Paediatrics. Philadelphia: Saunders Elsevier; 2007:1514-6.

Blanton R. Cysticercosis. In Behrman RE, Kliegman RM, Jenson HB (editors) Nelson Textbook of Pediatrics. 17th Ed Philadelphia, Saunders Company; 2004:1171-72.

Kossoff EH. Neurocysticercosis; 2003. available at 1573.htm.

Roman G, Sotelo J, Del Brutto O, Flisser A, Dumas M, Wadia N, et al. A proposal to declare neurocysticercosis an international reportable disease. Bull World Health Organ. 2000;78:399-406.

Del Brutto OH, Rajshekhar V, White AC, Tsang VC, Nash TE, Takayanagui OM, et al. Proposed diagnostic criteria for neurocysticercosis. Neurol. 2001;57:177‑83.

Garcia HH, Del Brutto OH. Imaging findings in neurocysticercosis Acta Trop. 2003;87:71-8.

Lerner MS, Shiroishi CS, Zee M, Law JL. Go Imaging of neurocysticercosis Neuroimaging Clin N Am. 2012;22:659-76.

Kimura-Hayama ET, Higuera JA, Corona-Cedillo R, Chavez-Macias L, Perochena A, Quiroz-Rojas LY, et al. Neurocysticercosis: radiologic-pathologic correlation Pediatr Neurol. 2000;11:354-69.

Shrestha BM. Childhood Neurocysticercosis: Clinicoradiological profile and outcome. J Nepal Paediatr Soc. 2008;28(1):14-6.

Bhattacharjee S, Biswas P, Mondal T. Clinical profile and follow-up of 51 pediatric neurocysticercosis cases: A study from Eastern India. Ann Indian Acad Neurol. 2013;16:549-55.

Singhi P, Dayal D, Khandelwal N. One Week versus four weeks of albendazole therapy for neurocysticercosis in children; a randomized, placebo controlled double blind trial. Ped Infect Dis J. 2003;22:268-72.

Chauhan RS. Clinical and radiological profile of neurocysticercosis and outcomes of treatment in neurocysticercosis in 62 children. Ind J Basic Appl Medic Res. 2016;5(3):271-9.

Kuruvilla A, Pandian JD, Nair M, Radhakrishnan VV, Joseph S. Neurocysticercosis: A clinical and radiological appraisal from Kerala State, South India. Singapore Med J. 2001;42:297-303.

Rajshekhar V, Raghava MV, Prabhakaran V, Oommen A, Muliyil J. Active epilepsy as an index of burden of neurocysticercosis in Vellore district, India. Neurol. 2006;67:2135-9.

Bala C. Diagnosis of neurocysticercosis among patients with seizures in northern coastal districts of Andhra Pradesh, India. Asian Pacific J Tropic Biomedic. 2016;6(11):9038.

Sahu PS, Patro S, Jena PK, Swain SK, Das BK. Imaging and serological-evidence of neurocysticercosis among patients with seizures in Odisha, an unexplored eastern coastal province in India. J Clin Diagn Res. 2015;9:DC06-10.

Talukdar B, Saxena A, Popli VK. Neurocystcercosis in Children: Clinical Characteristics and Outcome. Annal Tropl Paediatr. 2002;22:333-9.

Gauchan E, Malla T, Basnet S, Rao KS. Variability of presentations and CT-scan findings in children with neurocysticercosis. Kathmandu Univ Medic J. 2012;9(2):17-21.

Ruiz-García M, González-Astiazarán A, Rueda-Franco F. Neurocysticercosis in children. Clinical experience in 122 patients. Childs Nerv Syst. 1997;13(11-12):608-12.

Rosenfeld EA, Byrd SE, Shulman ST. Neurocysticercosis among Children in Chicago. Clin Infect Dis. 1996;23:262-8.

Zammarchi L. Profile of adult and pediatric neurocysticercosis cases observed in five Southern European centers. Neurol Sci. 2016;37(8):1349-55.