Study of hepatic dysfunction of dengue fever in children

Authors

  • Tamil Selvan Department of Paediatrics, Sapthagiri Institute of Medical Sciences and Research Centre,Bangalore,Karnataka,India
  • Saravanan P. Department of Paediatrics, Sapthagiri Institute of Medical Sciences and Research Centre,Bangalore,Karnataka,India
  • Nagaraj M.V. Department of Paediatrics, Sapthagiri Institute of Medical Sciences and Research Centre,Bangalore,Karnataka,India
  • Mrigender Nath Tudu Department of Paediatrics, Sapthagiri Institute of Medical Sciences and Research Centre,Bangalore,Karnataka,India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20171695

Keywords:

Dengue fever, Jaundice, Hepatic dysfunction

Abstract

Background: Dengue is a major international health concern that is prevalent in tropical and sub-tropical countries. It is estimated that worldwide nearly 2.5 billion people continue to live at risk of contracting the infection while 50 million cases and 24,000 deaths tend to occur in 100 endemic countries. Hepatic dysfunction is common in dengue fever and the degree of liver dysfunction in children varies from mild injury with to severe injury.

Methods: Prospective and descriptive study was conducted on all the laboratory confirmed cases of dengue fever in children admitted at SIMS and RC over a period of 1 year from Dec 2015 to Nov 2016 both clinically and biochemically.

Results: This study reveals, the prevalence of hepatic dysfunction in 30.6% (174/568) of the cases. Among the gender and age, majority of the hepatic dysfunction were seen in males 55.7% (97/174) and in the age group of 10-18 years 44.2% (77/174). Based on the severity, majority of hepatic dysfunction was seen in severe dengue cases 59.2% (103/174). Among clinical findings, most common symptom was jaundice 27.5% (48/174) and commonest sign was hepatomegaly 39.6% (69/174). The commonest liver function test altered was AST level in 45.4% (79/174) of the cases. Commonest abdominal USG finding was gall bladder edema in 90.8% (156/174) of the cases. The mortality was nil in this study.

Conclusions: This study concludes prevalence of hepatic dysfunction was seen 30.6%, most of them seen in severe dengue 59.2% of the cases suggesting any febrile child with hepatic dysfunction, dengue infection should be suspected.

References

World Health Organization; Dengue and Dengue Hemorrhagic fever. Available in www.who.int/media centre/factsheets./ fs117 /en/. Accessed on 19 April 2013.

Guzmán MG, Kourí G. Dengue: an update. Lancet Infect Dis. 2002;2:33-42.

Centers for disease control and prevention. Imported dengue - United States, 1997 and 1998. MMWR Morb. Mortal Wkly Rep. 2000:248-53.

World health Organization. Dengue and dengue haemorrhagic fever. Available at http// www.who.int/ mediacentre/factsheet s/fs117/en/. Accessed on 12 July 2016.

Kadar A, Kandasamy MS, Appavoo P, Anuradha CN. Outbreak and control of dengue in a village of Dharmapuri, Tamil Nadu. J Commun Dis. 1997;29:69.

Wiwanitkit V. Liver dysfunction in dengue infection, an analysis of the previously published Thai cases. J Ayub Med Coll Abbottabad. 2007;19(1):10-1.

Soundravally R, Narayanan P, Bhat B. Fulminant hepatic failure in an infant with severe Dengue infection. Indian J Pediatr. 2010;77(4):435-7.

Petdachai W. Hepatic dysfunction in children with dengue shock syndrome. Dengue Bulletin. 2005;29:112-7.

Mohan B, Patwari AK, Anand VK. Hepatic dysfunction in childhood dengue infections. J Trop Pediatr. 2000;46(1):40-3.

Wahid SF, Sanusi S, Zawawi MM, Ali RA. A comparison of the pattern of liver involvement in dengue hemorrhagic fever with classic dengue fever. Southeast Asian J Trop Med Pub Health. 2000;31(2):259-63.

Itha S, Kashyap R, Krishnani N. Profile of liver involvement in dengue virus infection. Natl Med J India. 2005;18(3):127-30.

Wong M, Shen E. The Utility of liver function tests in Dengue. Ann Acad Med. 2008;37(1):823.

Kamath SR, Ranjith S. Clinical features, complications and atypical manifestations of children with severe forms of dengue hemorrhagic fever in south India. Indian J Pediatr. 2006;73(10):889-95.

Seneviratne SL, Malavige GN, Silva HJ. Pathogenesis of liver involvement during dengue viral infections. Trans R Soc Trop Med Hyg. 2006;100(7):608-14.

Kumar R, Tripathi P, Tripathi S. Prevalence of dengue infection in north Indian children with acute hepatic failure. Ann Hepatol. 2008;7(1):59-62.

Poovorawan Y, Hutagalung Y, Chongsrisawat V. Dengue virus infection: a major cause of acute hepatic failure in Thai children. Ann Trop Paediatr. 2006;26(1):17-23.

World Health Organization. Dengue haemorrhagic fever: diagnosis, treatment, prevention and control. Second edition. Geneva: World Health Organization. 1997.

Nimmannitya S, Thisyakorn U, Hemsrichart V. Dengue hemorrhagic fever with unusual manifestations. Southeast Asian J Trop Med Public Health. 1987;18(3):398-405.

Wichmann O, Hongsiriwon S, Bowonwatanuwong C, et al. Risk factors and clinical features associated with severe dengue infection in adults and children the 2001 epidemic in Chonburi, Thailand. Trop Med Int Health. 2004;9(9):1022-9.

Faridi MMA, Aggarwal A, Kumar M, Sarafrazul A.Clinical and biochemical profile of dengue haemorrhagic fever in children in Delhi. Trop Doct. 2008;38(1):28-30.

Dhooria GS, Bhat D, Bains HS. Clinical profile and outcome in children of Dengue hemorrhagic fever in north India. Iran J Pediatr. 2008;18(3):222-8.

Chairulfatah A, Setiabudi D, Ridad A, Colebunders R. Clinical manifestations of Dengue fever in children in Bandung, Indonesia. Ann Soc Belge Med Trop. 1995;75(4):291-5.

Downloads

Published

2017-04-25

Issue

Section

Original Research Articles