DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20172700

A HLH is a rare fatal condition easily misdiagnosed as infectious disease

Md. Khaja Moinuddin, Premalatha R.

Abstract


Hemophagocytic lymphohistiocytosis (HLH) is characterized by clonal proliferation of the morphologically normal antigen processing cells, i.e. macrophages and CD8 lymphocytes in the involved tissue, due to uncontrolled activation of inflammatory cytokines. Two major forms include Familial HLH and infection associated hemophagocytic syndrome. Both these forms of HLH proceed with a generalized disease process i.e. fever, rashes and weight loss. Hence it is easily misdiagnosed as any infectious disease. So, a high index of suspicion is required for the diagnosis. With the help of clinical and laboratory criteria we can easily diagnose it without any genetic testing. 


Keywords


Bone marrow, Hemophagocytic lymphohistiocytosis, Macrophages

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References


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