Diagnosis of precocious puberty due to tuber cinereum hamartoma by clinicoradiologic correlation
Keywords:Tuber cinereum hamartoma, Precocious puberty
We present a case of a 3 year male child who presented with precocious puberty. Endocrinological studies revealed increased LH and increased testosterone. Bone age was 8 years. MR Imaging showed hypothalamic mass isointense to brain parenchyma on T1-WI and hyperintense on T2-WI, without contrast enhancement. Typical clinical presentation, endocrinological studies and MRI features strongly favoured the diagnosis of tuber cinereum hamartoma. This case is presented to emphasize the importance of clinicoradiologic correlation in the diagnosis of precocious puberty due to tuber cinereum hamartoma.
Amstutz DR, Coons SW, Kerrigan JF, Rekate HL, Heiserman JE. Hypothalamic hamartomas: correlation of MR imaging and spectroscopic findings with tumor glial content. AJNR Am J Neuroradiol. 2006;27(4):794-8.
Ng SM, Kumar Y, Cody D, Smith CS, Didi M. Cranial MRI scans are indicated in all girls with central precocious puberty. Arch Dis Child. 2003;88:414-41.
Engel J, Pedley TA, Aicardi J. Syndromes of late childhood. In: Engel J, Pedley TA, Aicardi J, eds. Epilepsy: A Comprehensive Textbook. 2nd ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2008: 2525.
Shah P, Patkar D, Patankar T, Shah J, Srinivasa P, Krishnan A. MR imaging features in hypothalamic hamartoma: a report of three cases and review of literature. J Postgrad Med. 1999;45:84-6.
de Brito VN, Latronico AC, Arnhold IJ, Lo LS, Domenice S, Albano MC, et al. Treatment of gonadotropin dependent precocious puberty due to hypothalamic hamartoma with gonadotropin releasing hormone agonist depot. Arch Dis Child. 1999;80:231-4.