Assessment of quality of life and its predictors in thalassemic children

Authors

  • Priykant Tomar Department of Neonatolgy, NSCB Medical College, Jabalpur, Madhya Pradesh, India
  • Deepak Kumar Patel Department of Pediatrics, CIMS Chhindwara, Madhya Pradesh, India
  • Chanchlesh Dehariya Department of Pathology, CIMS Chhindwara, Madhya Pradesh, India
  • Amit Agrawal Department of Pediatrics, Gandhi Medical College, Bhopal, Madhya Pradesh, India
  • Bharti Choubey Department of Pediatrics, GMC Bhopal, Madhya Pradesh, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20232877

Keywords:

Thalassemia, QOL, Children, Quality of life

Abstract

Background: In India, approximately 10,000 children are being born with thalassemia per year contributing to 10% of the total world incidence of thalassemia affected children. With the advancement in medical therapy resulting in early diagnosis and initiation of blood transfusion at an early age, and management of complications, survival rates have improved and such child can survive till second and third decades.

Methods: This study was conducted among 100 children in the age range of 2 to 14 years registered with the Thalassemia clinic, department of paediatrics, Gandhi Medical College and associated Kamla Nehru hospital, Bhopal. All patients underwent routine investigation and other relevant investigations as required. To assess the quality of life of children with thalassemia, pediatric quality of life inventory (PedsQL4) scale was used.

Results: Mean age of children belonging to the age range of less than 4 years- 38±11.38 months whereas that of children in the age range of 5-7 years and 8 to 12 years was 71.08±8.93 month’s and120.32±23.44 (95%CI 112.51-128.12) months respectively. The emotional domain of quality of life was significantly associated with compliance to chelation therapy among children in the age range of less than 4 and 8 to 12 years.

Conclusions: Thalassemia significantly affects negatively on the quality of life of all individuals irrespective of the age of the child. Though, all the domains i.e. physical, emotional, school and social are affected in these patients, physical and school domain are most commonly affected.

References

Aljeesh YI. Quality of life among thalassemia children patients in the Gaza strip. Sci Publish Group. 2016;5(3).

Sengupta M. Thalassemia among the tribal communities of India. Internet J Biol Anthropol. 2008;1(2).

Cao A. Quality of life and survival of patients with beta-thalassemia major. Haematologica. 2004;89(10):1157-9.

Dhirar N, Khandekar J, Bachani D, Mahto D. Thalassemia Major: how do we improve quality of life? Springerplus. 2016 28;5(1):1895.

Hakeem GLA, Mousa SO, Moustafa AN, Mahgoob MH, Hassan EE. Health-related quality of life in pediatric and adolescent patients with transfusion-dependent ß-thalassemia in upper Egypt (single center study). Health Qual Life Outcomes. 2018;16(1):59.

Rathaur VK, Imran A, Pathania M. Growth pattern in thalassemic children and their correlation with serum ferritin. J Family Med Prim Care. 2020;9(2):1166-9.

Devarshi SH, James SO, Najafzadeh EH, Pawar SU, Kalrao VI, Bafna VI. Assessment of quality of life, complications and post-transfusion adverse reactions in thalassemia pediatric in tertiary care hospital. Int J Pharm Pharm Sci. 2016;8:317-23.

Mikael NA, Al-Allawi NA. Factors affecting quality of life in children and adolescents with thalassemia in Iraqi Kurdistan. Saudi Med J. 2018;39(8):799-807.

Jafari-Shakib A, Davoudi-Kiakalaye A, Pour-Fathollah AA, Jafari-Shakib R, Mohtasham-Amiri Z. Health-related quality of life in β thalassemia major children in north of Iran. Iranian J Blood Cancer. 2016;8(4):108-11.

Mishra AK, Tiwari A. Iron overload in Beta thalassaemia major and intermedia patients. Maedica (Bucur). 2013;8(4):328-32.

Ayoub MD, Radi SA, Azab AM, Abulaban AA, Balkhoyor AH, Bedair SW, et al. Quality of life among children with beta-thalassemia major treated in Western Saudi Arabia. Saudi Med J. 2013;34(12):1281-6.

Thavorncharoensap M, Torcharus K, Nuchprayoon I, Riewpaiboon A, Indaratna K, Ubol BO. Factors affecting health-related quality of life in Thai children with thalassemia. BMC Blood Disord. 2010;10:1.

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Published

2023-09-27

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Original Research Articles