Pediatric giant cell glioblastoma: a rare entity

Poornima Vijayan, Zuhara Shemin, Sharmina Saleem, Anupama Ponniah


Giant cell glioblastoma (GCG) is a rare subtype of glioblastoma multiforme (GBM) which represents 0.8% of all brain tumors and 5% of glioblastomas. This entity is all the more rarer in the pediatric age group. And, due to the limited number of case reports and case series in literature, its epidemiology, natural history and follow up are not well documented. We present this case for its rarity. A 14-year-old girl presented with history of recent onset headache and vomiting from last 10 days. Magnetic resonance imaging (MRI) brain revealed a mass lesion in the right temporo-parietal region, suggestive of a high-grade glioma. Histopathological examination revealed features typical of giant cell glioblastoma. Giant cell glioblastoma, is an extremely rare variant of gliobastoma multiforme, merits special mention because it has been hypothesized to be associated with a longer survival compared with GBM in both adults and children, possibly because of the younger age at presentation, certain histopathological and molecular characteristics of this entity.


Giant cell glioblastoma, Long term survival, Pediatric

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Kleihues P, Burger PC, Aldape KD. Glioblastoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, editors. WHO Classification of Tumors of the Central Nervous System. Lyon, France: IARC Press; 2007:33-49.

Karremann M, Butenhoff S, Rausche U, Pietsch T, Wolff JEA, Kramm CM. Pediatric giant cell glioblastoma: New insights into a rare tumor entity. Neuro Oncol. 2009;11(3):323-9.

Belsuzarri TAB, Araujo JFM, Catanoce AP. Giant cells glioblastoma: case report and pathological analysis from this uncommon subtype of glioma. Rare Tumors. 2015;7(1):5634.

Jain SK, Sundar IV, Sinha VD, Sharma V, Bhasme V, Goel RS. Giant cell glioblastoma in a child: a rare case report. Asian J Neurosurg. 2012;7(3):144-6.

Borkar SA, Lakshmiprasad G, Subbarao KC, Sharma MC, Mahapatra AK. Giant cell glioblastoma in the pediatric age group: Report of two cases. J Pediatr Neurosci. 2013;8(1):38-40.

Katoh M, Aida T, Sugimoto S. Immunohistochemical analysis of giant cell glioblastoma. Pathol Int. 1995;45:275-82.

Shinojima N, Kochi M, Hamada JI. The influence of sex and the presence of giant cells on postoperative long-term survival in adult patients with supratentorial glioblastoma multiforme. J Neurosurg. 2004;101:219-26.