Autoimmune hemolytic anemia: a rare case report in a post-COVID patient
DOI:
https://doi.org/10.18203/2349-3291.ijcp20222779Keywords:
AIHA, SARS-CoV-2 infection, Hemolysis, Inflammatory stateAbstract
Autoimmune hemolytic anemia (AIHA), a rare disease in pediatrics, affecting one’s own immune system, is one of the causes for the acquired hemolytic anemia. For the past two years, the COVID-19 pandemic had emerged, evolved and manifested with a wide range of symptoms causing threat to human race. In recent times, there have been literatures focused on AIHA manifesting, with novel SARS-CoV-2 infection, or as its late sequelae (secondary). The pathophysiology causing hemolysis in SARS-CoV-2 infection remains vague making it a very rare association with COVID-19. The acute symptoms of jaundice, giddiness, shortness of breath are noted, with investigations depicting hyper-inflammatory state as a most common etio-pathogenesis. This acute presentation, at times could be fatal and make the patient refractory to steroids. There are complications due to COVID-19 infection like pneumonia, respiratory failure, acute respiratory distress syndrome etc.,known until lately where AIHA secondary to COVID-19, a very rare phenomenon is taking the spot light. A few cases of AIHA manifestation with ongoing SARS-CoV-2 have been reported and few cases which presented as a secondary infection. Here we are presenting an extremely rare case of a 16-year-old girl, with late onset anemia, post COVID-19 infection 4 weeks back.
References
Lazarian G, Quinquenel A, Bellal M. Autoimmune Hemolytic Anemia Associated with COVID-19 Infection. Brit J Hematol. 2020;190:29-31
Arunpriyandan V, Kumanan S, Pakkiyartam M. First Case of Autoimmune Hemolytic Anemia Associated With COVID-19 Infection in Sri Lanka: A Case Report. Cureus. 2021;1(10).
Al Khoufi E, Al-Muhiany B, Al-Gadeeb A. Autoimmune Hemolytic Anemia; A Late Presentation of Post COVID-19 Syndrome. OMJ. 2023;05:10-5001.
Naithani R, Agarwal N, Mahapatra M. Autoimmune Hemolytic Anemia in India: Clinico-hematological Spectrum of 79 Cases. 2006;11(1):73-6.
Lakshmi J. Nair, Aravind Regukumar, K. T. Baalamurugan. COVID-19- Associated Severe Autoimmune Hemolytic Anemia: A Rare Case Report. Saudi Journal of Medical Sciences. Sept-Dec 2021;vol 9:276-279
Reddy VRS, Samayam P, Ravichander B. Autoimmune Hemolytic Anemia: Mixed type-A Case Report. Ind J Hematol Blood Transfus. 2011;27(2):107-10.
Phillips J, Henderson AC. Hemolytic Anemia-Evaluation and Differential Diagnosis. Am Family Phys. 2018;98(6):354-61.
V Padma and B Abhilash Nair. Autoimmune Hemolytic Anemia-An Interesting Case Report. Ind J Clin Pract. 2020;31(3):266-9.
Palla AR, Khirmani F, Craig MD. Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG : A case Study and Analytical Literature Review of Incidence and Severity. Clin Med Insights: Case Rep. 2013;6:57-60.