Prospective longitudinal observational study in assessing prognostic accuracy of sequential organ failure assessment and quick-sequential organ failure assessment scores in detecting morbidity and mortality in critically ill children
DOI:
https://doi.org/10.18203/2349-3291.ijcp20213730Keywords:
Sepsis, SOFA, Q-SOFAAbstract
Background: The objective of the study was to assess prognostic accuracy of SOFA (sequential organ failure assessment score) and Q-SOFA (quick-sequential organ failure assessment) score in detecting morbidity and mortality in critically ill children admitted in our intensive care unit.
Methods: All critically ill children admitted were recruited over a time period of 7 months. Q-SOFA score was assessed at presentation, followed by SOFA score on day 1 and day 2 of ICU stay and outcome was observed.
Results: Total of 272 sick children were recruited and assessed. All eight (2.94%) mortalities had high Q-SOFA score of three (p<0.001), mean SOFA (day 1) score 11.12±0.99 (p<0.001), mean SOFA (day 2) was 11.62±1.40 (p<0.001).
Conclusions: Q-SOFA is a simple, inexpensive and rapid test to assess and predict sick children requiring ICU care in emergency department. High SOFA score predicts high probability of mortality and detects organ failure early.
Metrics
References
Bhutta ZA, Black RE. Global maternal, newborn, and child health-so near and yet so far. N E J Med. 2013;369(23):2226-35.
Sarthi M, Lodha R, Vivekanandhan S, Arora NK. Adrenal status in children with septic shock using low-dose stimulation test. Pediatr Crit Care Med. 2007;8(1):23-8.
Proulx F, Fayon M, Farrell CA, Lacroix J, Gauthier M. Epidemiology of sepsis and multiple organ dysfunction syndrome in children. Chest. 1996;109(4):1033-7.
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801-10.
Matics TJ, Sanchez-Pinto LN. Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the sepsis-3 definitions in critically ill children. JAMA Pediatr. 2017;171(10):172352.
Weiss SL, Fitzgerald JC, Pappachan J, Wheeler D, Jaramillo-Bustamante JC, Salloo A, et al. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respirat Crit Care Med. 2015;191(10):1147-57.
Magee JC, Krishnan SM, Benfield MR, Hsu DT, Shneider BL. Pediatric transplantation in the United States, 1997–2006. Am J Transplant. 2008;8:935-45.
Wen SW, Smith G, Yang Q, Walker M. Epidemiology of preterm birth and neonatal outcome. Semin Fetal Neonatal Med. 2004;9(6):429-35.
Mehta Y, Kochhar G. Sepsis and septic shock. J Card Crit Care. 2017;1(01):3-5.
Goldstein B, Giroir B, Randolph A. International Consensus Conference on Paediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6(1):2-8.
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. International sepsis definitions conference. Intens Care Med. 2003;29(4):530-8.
Churpek MM, Snyder A, Han X, Sokol S, Pettit N, Howell MD, et al. Quick sepsis-related organ failure assessment, systemic inflammatory response syndrome, and early warning scores for detecting clinical deterioration in infected patients outside the intensive care unit. Am J Respirat Crit Care Med. 2017;195(7):906-11.
Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 2015;372(17):1629-38.
Tekade T, Manohar T. Utility of SOFA (sequential organ function assessment) score to predict outcome in critically ill patients at a tertiary care hospital, Nagpur. Panacea J Med Sci. 2017;7(3):140-6.
Raith EP, Udy AA, Bailey M, McGloughlin S, MacIsaac C, Bellomo R, et al , Prognostic accuracy of the SOFA score, SIRS criteria, and qSOFA score for in-hospital mortality among adults with suspected infection admitted to the intensive care unit. JAMA. 2017;317(3):290-300.