A study to estimate similarities or dissimilarities of thyroid parameters of cord blood and new-born venous blood amongst new-borns
Keywords:Cord and capillary blood, TSH, T3 and T4
Background: Hypothyroidism may be congenital or may be acquired which might or may not have a delayed onset. Incomplete thyroid development and decreased thyroid hormone biosynthesis is a result of congenital hypothyroidism. Screening is usually missed in areas where testing is not done and being the reason for new cases of hypothyroid cases. The aim was to assess/evaluate whether cord blood can be used as a primary screening method for congenital hypothyroidism.
Methods: The study was taken up in the department of pediatrics of a tertiary teaching hospital. A total of 200 babies were taken for the study during the whole study period. The cord blood at the time of delivery and 48 hour serum blood was collected and sent to the lab for thyroid profile estimation.
Results: The study consisted of 109 males and 91 female infants. Among the 200 subjects, 156 were term babies and 44 preterm. The mean birth weight was 2.44 kgs. The mean cord TSH was 6.89±4.56, the mean T3 level was 81.03±38.84 and mean T4 level among the subjects was 11.17±3.33. The capillary venous blood was collected after 48 hours for thyroid profiling. The mean TSH was 5.15±3.13, mean T3 level was 111.53±36.49 and mean T4 level was 14.65±6.07. On comparison of cord blood and venous blood association was noted between them.
Conclusions: From the present study findings it can be suggested cord blood can be used as a marker for early detection of congenital hypothyroidism.
Wassner AJ, Smith JR. Hypothyroidism. In: Kliegman RM, eds. Nelson Textbook of Pediatrics. 21st ed. New Delhi: Elsevier; 2020: 11398-421.
Rastogi MV, LaFranchi SH. Congenital hypothyroidism. Orphanet J Rare Dis. 2010;5:17.
Deladoey J, Ruel J, Giguere Y, Vliet GV. Is the incidence of congenital hypothyroidism really increasing? A 20 year retrospective populationbased study in Quebec. J Clin Endocrinol Metab. 2011;96(8):2422-9.
Rahmani K, Yarahmadi S, Etemad K, Mehrabi Y, Aghang N, Khoosha A, et al. Intelligent quotient at the age of 6 years of Iranian children with congenital hypothyroidism. Indian Pediatr. 2018;55:121-4.
Agrawal P, Philip R, Saran S, Gutch M, Razi MS, Agroiya P, et al. Congenital hypothyroidism. Indian J Endocrinol Metab. 2015;19(2):221-7.
Verma IC, Bijarnia‑Mahay S, Jhingan G, Verma J. Newborn screening: need of the hour in India. Indian J Pediatr. 2015;82(1):61‑70.
Prabhu SR, Mahadevan S, Jagadeesh S, Suresh S. Congenital hypothyroidism: recent Indian data. Indian J Endocrinol Metab. 2015;19(3):436-7.
Raj S, Baburaj S, George J, Abraham B, Singh S. Cord blood TSH level variations in newborn-experience from a rural centre in Southern India. J Clin Diagn Res. 2014;8(7):18-20.
Armanian AM, Hashemipour M, Esnaashari A, Kelishadi R, Farajzadegan Z. Influence of perinatal factors on thyroid stimulating hormone level in cord blood. Adv Biomed Res. 2013;2:48.
Poyekar S, Pratinidhi S, Prasad SS, Sardar ZS, Kankariya B, Bhole O. Cord blood thyroid stimulating hormone level and the influence of perinatal and other factors on it. Pediatr Oncall J. 2019;16:79-82.
Lakshminarayana SG, Sadanandan NP, Mehaboob A K, Gopaliah LR. Effect of maternal and neonatal factors on cord blood thyroid stimulating hormone. Indian J Endocr Metab. 2016;20(3):317-23.
Adeniran KA, Okolo AA, Onyiriuka AN. Thyroid profile of term appropriate for gestational age neonates in Nigeria: a forerunner to screening for congenital hypothyroidism. J Trop Pediatr. 2010;56(5):329-32.
Choudhary SS, Langade RA, Kshirsagar VY. Normal values and variation of thyroid stimulating hormone (TSH) in cord blood of babies born over a period of 1 year. Int J Res Pharmaceut Sci. 2020;11(3):3177-82.
Gupta A, Srivastava S, Bhatnagar A. Cord blood thyroid stimulating hormone level-interpretation in light of perinatal factors. Indian Pediatr. 2014;51(1):32-6.
Bhatia R, Rajwaniya D, Paul IS. Cord blood thyroid-stimulating hormone level: interpretation in light of antenatal and perinatal factors. J Neonatol. 2018;32(4):87-92.