Study on effect of antenatal steroids on various outcomes in mechanical ventilated low birth weight neonates admitted to neonatal intensive care unit


  • Madhu G. N. Department of Paediatrics, Kempegowda Institute of Medical Sciences, Bangalore, Karnataka, India
  • Anil H. Department of Paediatrics, Kempegowda Institute of Medical Sciences, Bangalore, Karnataka, India



Antenatal steroids, Low birth weight neonates, Mechanical ventilation


Background: There has been an increase in morbidity in low birth weight infants, since the advancement in field of neonatology. Mechanical ventilation is one of the important life saving intervention in these babies and if prolonged, it is known to cause various morbidities like bronchopulmonary dysplasia, retinopathy of prematurity, vocal cord injury. In this study we want to know effect of antenatal steroids on assisting in early extubation and in minimising duration of ventilation and prevention of reintubations.

Methods: This study is a prospective observational study. The study was conducted in Kempegowda institute of medical sciences, Bangalore. Total of 60 low birth weight infants (<2500gm) who were admitted to the Neonatal Intensive Care Unit (NICU) and were on mechanical ventilator support were included in the study. The study was conducted for a duration of 18 months, between January 2019 to June 2020.

Results: Out of 60 cases 49 of neonates underwent successful extubation and 11 had failed extubation and were reintubated. Out of 49 successful extubation cases 18 mothers were not given antenatal steroids and 7 of them received 1 dose and 24 received 2 doses of betamethasone respectively. Among failed extubation group 7 mothers had not received steroids and 2 had received one and 2 doses respectively.

Conclusions: In this study, we were able to know the effect on antenatal steroids on duration of mechanical ventilation and also about their effect on extubation success.



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