DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20205094

A study of etiological and clinical profile of short stature in a tertiary care center

Nagajyothi Penugonda, Ramkumar Selvarajan, Balasubramaniam Ramakrishnan

Abstract


Background: Short stature is the common finding in pediatric endocrine practice with diverse etiology. However, compared to western world, data addressing the etiological and clinical profile of short stature in India are limited. The present study aimed to evaluate etiological and clinical profile of short stature in children. The primary objective was to identify children with short stature and evaluate various causes of short stature and secondary objective was to identify the gender and height differences among the different causes of short stature.

Methods: This prospective observational study analysed the data of 100 children aged 2-16 years, who presented to the department of paediatrics, Apollo Hospital, Chennai for the evaluation of short stature and poor growth during the period of April 2016 to April 2017.

Results: The predominant causes of short stature were growth hormone deficiency (GHD; 28%), normal variant short stature (26%), followed by chronic disease (8%), syndromic short stature (8%), Turner syndrome (7%), and hypothyroidism (6%). The most common causes of short stature in males were GHD (28%), constitutional delay of growth and puberty (CDGP; 24%) and familial short stature (FSS; 16%), whereas in females GHD (28%), Turner syndrome (14%) and FSS (12%). Beside this, 96% children had <3rd height centile and 4% children had >3rd height centile, of which 3 cases of GHD and 1 case of syndromic short stature were identified.

Conclusions: The most common causes of short stature identified in our study were GHD and normal variant short stature.


Keywords


Growth hormone deficiency, Normal variant short stature, Turner syndrome, Short stature, Constitutional delay in growth and puberty, Familial short stature

Full Text:

PDF

References


Miller BS, Zimmerman D. Idiopathic short stature in children. Pediatric Ann. 2004;33:177-81.

Kamboj M. Short stature and growth hormone. Indian J Pediatr. 2005;72:149-57.

Khadilkar V, Yadavas S, Agawam KK, Tambala S, Banerjee M, Cherian A, et al., Revised IAP growth charts for height, weight and body mass index for 5- to 18-year-old Indian children. Ind Pediatr. 2015;52:47-55.

Bhadada SK, Agrawal NK, Singh SK, Agrawal JK. Etiological Profile of Short Stature. Indian J Pediatr. 2003;70(7):545-7.

Dutta D, Biswas K, Arora R, Barman N, Bhushan D, Bhakhri BK. Profile and Height Outcomes of Children with Short Stature in North India: An Experience from a Tertiary Care Centre. Ind J Pediatr. 2014;81(2):205-6.

Lashari SK, Korero HB, Memo YM. To determine frequency of etiological factors in short statured patients presenting at an endocrine clinic of a tertiary care hospital. Pak J Med Sci. 2014;30(4):858-61.

Sultan M, Afzal M, Qurush SM, Aziz S, Lotmullah M, Khan SA, et al. Etiology of short stature in children. J Coll Physicians Surg Pak. 2008;18(8):493-7.

Rabbani MW, Khan WI, Afzal AB, Rabbani W. Causes of short stature identified in children presenting at a tertiary care hospital in Multan Pakistan. Pak J Med Sci. 2013;29(1):53-7.

Song KC, Jin SL, Kwon AR, Chae HW, Ahn JM, Kim DH. Etiologies of short stature. Ann Pediatric Endocrinol Metab. 2015;20:34-9.

Coutant R, Carel JC, Letrait M, Bouvattier C, Chatelain P, Coste J, et al. Short stature associated with intrauterine growth retardation, final height of untreated and growth hormone-treated children. J Clin Endocrinol Metab. 1998;83(4):1070-4.

Abuzzahab MJ, Schneider A, Goddard A, Grigorescu F, Lautier C, Keller E, et al. IGF-1 receptor mutations resulting in intrauterine and postnatal growth retardation. N Engl J Med. 2003;349:2211-22.

Singh P, Sharma PK, Agnihotri A. Coeliac disease in patients with short stature: a tertiary care centre experience. Natl Med J India 2015; 28: 176–180.

Papadimitriou A, Douros K, Papadimitriou DT, Kleanthous K, Karapanou O, Fretzayas A. Characteristics of the short children referred to an academic paediatric endocrine clinic in Greece. J Paediatr Child Health. 2012;48:263-7.