Symptomatic COVID-19 re-infection in a child, three months after primary infection

Authors

  • Serena M. Varghese Department of Pediatrics, Rajagiri Hospital, Aluva, Kerala, India
  • Mubeena M. Department of Pediatrics, Rajagiri Hospital, Aluva, Kerala, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20205106

Keywords:

COVID-19, SARS- CoV-2, RT-PCR, Genexpert, PIMS, Re-infection

Abstract

The natural course of Coronavirus disease 2019 (COVID-19) is still not fully known. Re-infection with Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in recovered children has not been reported till date. We describe a case of symptomatic COVID-19 re-infection in a child after an asymptomatic period of three months following an international travel. The child had RT-PCR positivity and systemic inflammation, but did not have multi organ dysfunction as in pediatric inflammatory multisystem syndrome.

References

Widders A, Broom A, Broome J. SARS-CoV-2: The viral shedding and infectivity dilemma. Infect Dis Health. 2020;25(3):210-5.

Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, et al. Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. J Am Med Assoc. 2020;323(15):1488-94.

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395 (10229):1054-62.

Zheng S, Fan J, Yu F, Feng B, Lou B, Zou Q, et al. Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study. BMJ. 2020;369:m1443.

Wolfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Marcel MA, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020;581:465-69.

To KK, Tsang OT, Leung WS, Tam AR, Wu TC, Lung DC, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during Winfection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis. 2020;20(5):565-74.

Zhu L, Gong N, Liu B, Lu X, Chen D, Chen S, et al. Coronavirus disease 2019 pneumonia in immunosuppressed renal transplant recipients: a summary of 10 confirmed cases in Wuhan, China. Eur Urol. 2020;77(6):748-54.

Liu WD, Chang SY, Wang JT, Tsai M J, Hung CC, Hsu CL, et al. Prolonged virus shedding even after seroconversion in a patient with COVID-19. J Infect. 2020;81(2):318-56.

To KK, Hung IF, IP JD, Chu AW, Chan W, Tham AR, et al. COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing. Clin Infect Dis. 2020;1275.

Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P, et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA. 2020;324(3):259-69.

Downloads

Published

2020-11-24

Issue

Section

Case Reports