A study of association between vitamin d deficiency in sepsis

Authors

  • Nishat Ahmed Department of Pediatrics, S. P. Medical College, Bikaner, Rajasthan
  • Vikram Yadav Department of Pediatrics, S. P. Medical College, Bikaner, Rajasthan
  • Rajendra Kumar Soni Department of Pediatrics, S. P. Medical College, Bikaner, Rajasthan
  • Niranjan Nagaraj Department of Pediatrics, S. P. Medical College, Bikaner, Rajasthan
  • Pramod Kumar Berwal Department of Pediatrics, S. P. Medical College, Bikaner, Rajasthan
  • Gunshyam Singh Sengar Department of Pediatrics, S. P. Medical College, Bikaner, Rajasthan

DOI:

https://doi.org/10.18203/2349-3291.ijcp20163690

Keywords:

Bikaner, Immune system, Sepsis, Vitamin D

Abstract

Background:Vitamin D is a fat-soluble steroid hormone that contributes to the maintenance of normal calcium homeostasis and skeletal mineralization the aims of this study is to evaluate vitamin D levels in pediatric patients admitted in the intensive care unit with sepsis.

Methods: Fifty children between 1 year to 12 years of age with systemic inflammatory response syndrome (SIRS) with suspected or proven sepsis, admitted in PICU were included for the study. Blood was drawn at the time of admission on the first day of hospital stay for measurement of 25-hydroxyvitamin D (25-OHD) levels.

Results:Forty two (84%) patients out of 50 patients had vitamin D levels < 30ng/ml and only 8 patients had vitamin D >30 ng/ml. This was statistically significant as the p value was <0.05.

Conclusions:Lower 25-OHD levels are associated with sepsis. The multiple functions of vitamin D in the immune system’s response to infection suggest it may be an integral component in combating sepsis.  

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Published

2016-12-22

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Original Research Articles