Association of bone age with overweight and obesity in children in the age group of 8 to 11 years
DOI:
https://doi.org/10.18203/2349-3291.ijcp20161882Keywords:
Obesity and bone age, Paediatric obesity, Early bone age advancement, Overweight and obesityAbstract
Background:Obesity is one of the most common nutritional problems in developed countries. The prevalence of obesity is rapidly progressing in children. It is associated with serious health hazards in adolescence and especially in adulthood, like hypertension, coronary artery disease, diabetes mellitus, etc.
Methods: A cross sectional study was conducted on 60 children fulfilling the inclusion criteria aged 8 to 11 years, of which 30 children were obese and 30 children were overweight. The body mass index (BMI) values of the children were plotted against the corresponding WHO charts. Children were segregated as overweight and Obese based on the BMI. Based on a radiological examination of skeletal development of the left-hand wrist, bone age is assessed and then compared with the chronological age.
Results:Among the study population the mean bone age index of obese children was 1.08615 and the mean bone age index of overweight children was 0.98097 which was statistically significant. Bone age index=0.016 (BMI)+0.6742. By using this formula we derived that a BMI of 19 or above triggered significant acceleration of bone age.
Conclusions:In our study by deriving at the bone age index of both obese and overweight children and comparing them, we found that the trends of obesity affecting the bone age is significantly more than overweight children. Hence the lifestyle modifications in overweight children are vital so as not to get into obese category. This will prevent the bone age changes which in turn will avoid serious health hazards in adolescence and especially in adulthood.
References
Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. J Am Med Asso. 2014;311(8):806-14.
National center for health statistics. health, united states, 2011: with special features on socioeconomic status and health. Hyattsville, MD; U.S. Department of Health and Human Services;2012.
Ells, Campbell K, Lindstone J, Kelly S, Lang R, Summerbell C. Prevention of childhood obesity. Best Pract Res Clin Endocrinol Metab. 2005;19:441-54.
Baskin ML, Ard J, Franklin F, Allison DB. Prevalence of obesity in the United States. Obes Rev. 2005;6:5-7.
Dehghan M, Akhtar DN, Merchant AT. Childhood obesity, prevalence and prevention. Nutr J. 2005;4:24.
Bhave S, Bavdekar A, Otiv M. IAP national task force for childhood prevention of adult diseases: childhood obesity. Indian Pediatr. 2004;41:559-75.
Dietz WH. Overweight in childhood and adolescence. N Engl J Med. 2004;350:855-7.
Haeusler G, Wakter I, Helmreich M, Egerbacher M. Location of matrix metalloproteinases (MMPs), their tissue inhibitors, and vascular endothelial growth factor (VEGF) in growth plates of children and adolescents indicates a role for MMPs in human postnatal growth and skeletal maturation. Cacif Tissue Int. 2005;76:326-35.
Grumbach MM. Estrogen, bone, growth and sex: a sea change in conventional wisdom. J Pediatr Endocrinol Metab. 2000;13(6):1439-55.
Klein KO, Lamore KA, Delancey E, Brown JM, Considine RV, Hassink SG. Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children. J Clin Endocrinol Metab. 1998;83:3469-74.
Russell DL, Keil MF, Bonat SH, Uwaifo GI, Nicholson JC, Mcduffie JR, et al. The relation between skeletal maturation and adiposity in African American and Caucasian children. J Pediatr. 2001;139:844-8.
He Q, Karlberg J: BMI in childhood and its association with height gain, timing of puberty, and final height. Pediatr Res. 2001;49:244-51.
Sopher AB1, Jean AM, Zwany SK, Winston DM, Pomeranz CB, Bell JJ, et al. Bone age advancement in prepubertal children with obesity and premature adrenarche: possible potentiating factors. Obesity (silver spring). 2011;19(6):1259-64.
Dorst JP. Radiography of infants and children. Am J Dis Child. 1964;107(1):107-8.
Greulich WW, Pyle SI: Radiographic atlas of skeletal development of hand wrist, 2nd ed. Stanford, CA: Standford Univ Press, 1971.
Murray RO. Assessment of skeletal maturity and prediction of adult height (TW2 Method). Proc R Soc Med. 1976;69(7):542.
Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. J Am Med Asso. 2002;288:1728-32.
Petrou V, Tertipi A, Georgoulas T, Papastathi E, Deligeorgi M, Skarpa V, et al. Childhood obesity and bone age. Endocrine Abstracts. 2009;20:528.
Chaumoitre K, Lamtali S, Baali A, Saliba-Serre B, Lahmam A, Aboussad A, et al. Influence of socioeconomic status and body mass index on bone age. Horm Res Paediatr. 2010;74:129-35.
Pinero J, Rabinovich RR, Alaia MJ, Feldman DS, Otsuka NY. Does body mass influence skeletal age: an analysis using the tanner-whitehouse 3 method. J Orthopaedics. 2012;9(2):2.
Sopher AB, Jean AM, Zwany SK. Bone age advancement in prepubertal children with obesity and premature adrenarche: possible potentiating factors. Obesity. 2011;19(6):1259-64.