Evaluation of neuro-developmental outcome among babies with meconium aspiration syndrome

Suhaim Afsar, Naresh P. Motwani, Sudhakar C., Uma Chaturvedi


Background:Meconium aspiration syndrome (MAS) is respiratory distress in a neonates caused by the presence of meconium in the tracheobronchial airways. Despite adequate management, there is a high risk of morbidity in the form of seizures, cerebral palsy, mental retardation, respiratory problems of childhood and mortality. Hence, this study was performed in view of developmental issues concerning young infants and pre-school children as maximum brain growth happens in the first three years of life.

Methods: This was a prospective study conducted in Chandulal Chandrakar memorial hospital, Bhilai from 1st September 2013 to 31st February 2015, with history of meconium stained amniotic fluid (MSAF) in both out-born and in-born neonates. Neonates after meeting inclusion criteria were included in the study. The data were recorded in pre-designed proforma. The data were analyzed using appropriate Chi square test. Level of significance was set at p <0.05.

Results:Incidence of MAS was significantly more in children of >2.5 kgs (80%) and common in primiparous mothers (60%) with lower segmental caesarian sections. MAS commonly seen in post -term babies (53.33%) than those of term (36.66%) or pre-term (10%) gestation. Fetal distress was the common complication observed in most of the cases (91.1%) and one death related to this was noted. At the end of 1 year there were predominantly more children (40%) who developed respiratory morbidities. Delayed development was seen among 13.3% children, transient tone abnormalities were noted in about 2% of infants.

Conclusions:The findings of the present study suggest that neonates diagnosed with MAS displayed neuro-developmental delay in13% cases. This study gave an overview of all meconium aspiration cases and the neuro-developmental outcome in these babies. However further research should be done with large sample size to confirm these findings.



Foetal distress, MAS, Neuro-developmental outcome

Full Text:



Wiswell TE, Tuggle JM, Turner BS. Meconium aspiration syndrome: have we made a difference? Pediatrics. 1990;85(5):715-21.

Yeh TF, Harris V. Roentegraphic findings in infants with meconium aspiration syndrome. JAMA. 1979;242:60.

Finer NN, Richards RT, Peters RN. Hypoxic ischemic encephalopathy in term neonates: perinatal factors and outcome. The journal of pediatrics. 1981;98:112.

Todres ID, Rogers MC. Neonatal resuscitation. JAMA. 1992;268:16.

Cochran WG. Sampling techniques. 3rd ed. New York. John Wiley and Sons; 1977:81.

Cleary GM, Wiswell TE. Meconium stained amniotic fliuid and MAS. An update. Ped Clin North AM. 1998;45(3):511-25.

Berkus MD, Langen O, Samueloff A, Xenakis EM, Field NT, Ridgway LE. Meconiumstained amniotic. uid: increased risk for adverse neonatal outcome. Obstet Gynecol. 1994;84:115.

Wiswell TE, Bent RC. Meconium staining and meconium aspiration syndrome. Ped Clin North Am. 1993;40:957.

Bascik RD. Meconium aspiration syndrome. Pediatr Clin North Am. 1977;24:467.

Gregory GA, Charles A, Roderic H. Meconium aspiration in infants: a prospective study. The journal of paediatrics. 1974;85:848.

Gupta V, Bhatia BD. Meconium stained amniotic fluid: antenatal and neonatal attributes. Indian Paediatrics. 1996;33:293.

González de Dios J, Moya Benavent M, Barbal Rodoreda A, Dura Trave T, Juste Ruiz M, Castaño Iglesias C, et al. Neonatal morbidity associated with meconium stained amniotic fluid. An Esp pediatr. 1998;48:54.

Sasikala A, Raghavan S. Perinatal outcome in relation to mode of delivery in meconium stained amniotic fluid. Indian journal of paediatrics. 1995;62:63.

Beligere N, Rao R. Neurodevelopmental outcome of infants with meconium aspiration syndrome: report of a study and literature review. J Perinatol. 2008;28(3):93-101.

Anwar Z, Butt TK, Anjum F, YaqubKazi Md. Mortality in meconium aspiration syndrome in hospitalized babies. Journal of the College of Physicians and Surgeons Pakistan. 2011;21(11):695-9.