A study on thyroid function test in children with nephrotic syndrome


  • Jasashree Choudhury Department of Pediatrics, IMS and SUM Hospital, Kalinga Nagar, Bhubaneswar, Odisha




Hypothyroidism, Nephrotic syndrome, T3, T4, TSH


Background:This is a comparative study which was conducted to find out any impact of nephrotic syndrome on status of thyroid hormone level in children with nephrotic syndrome.

Methods: Study was done from December 2014 to December 2015 at a tertiary care hospital in BBSR, Odisha. The study was carried out in total of  60 children of age between 1-8 years out of which 30 children(N group) were admitted for reason other than nephrotic syndrome(excluding known cases of thyroid disorder) and 30 children were  suffering from nephrotic syndrome (NS group). Thyroid hormone level (T3, T4 and TSH) was tested in all children.

Results: The T4 and T3 levels in nephrotic syndrome (NS group) patients were low. TSH level were high in NS group. T4 level was low in NS group in comparison to N group which was statistically significant. Hypothyroidism was found more in younger children <6 years of age in comparison to children >6 years which was statistically significant.

Conclusions: This study concluded that incidence of hypothyroidism was more in children with nephrotic syndrome.


Kaptein EM. Thyroid function in renal failure. Contributions to Nephrology. 1986;50:64-72.

Campbell AG, McIntosh N. Endocrine gland disorders in Klenar CJ, Forfar and Areil’s text book of paediatrics. 4th ed. London New York and Tokyo: Campbell, A.G. and McIntosh N; 1992.

Katz Al and Lindheimer MD. Actions of hormones on the kidney. Ann Rev Physiol. 1977;39:97-133.

Niloofar H, Sayed M, Behnam N. Examine of thyroid function in pediatric nrphrotic syndrome. Intern J Pediatr. 2015;3(2):59-65.

Schussler GC. The thyroxine-binding proteins. Thyroid. 2000;10:141-9.

Katz Al, Emmanuel DS, Marshall DL. Thyroids hormone and the kidney. Nephron. 1975;15:223-49.

Iglesias P, Diez JJ. Thyroid dysfunction and kidney disease. Eur J Endocrinol. 2009;160:503-15.

Matto TK. Hypothyroidism in infants with nephrotic syndrome. Pediatric Nephrology. 1994;8(6):657-9.

Ito S, Kano K, Ando T, Ichimura T. Thyroid function in children with nephrotic syndrome. Pediatr Nephrol. 1994;8(4):412-5.

Sawant BU, Nadkarni GD, Thakare UR, Joseph LJ, Rajan MGR. Changes in lipid peroxidation and free radical scavengers in kidney of hypothyroid and hyperthyroid. 2003:1334-7.

Gilles R, den Heijer M, Ross AH, Sweep FC, Hermus AR, Wetzels JF. Thyroid function in patients with proteinuria. Netherlands J Med. 2008;66(11):483-5.

Iglesias P, Diez JJ. Thyroid dysfunction and kidney disease. European J Endocrinol. 2009;160:503-15.

Afroz S, Khan AH, Roy DK. Thyroid function in children with nephrotic syndrome. Mymensingh Med J. 2011;20(3):407-11.

Kaptein EM, Hoopes MT, Praise M, Massry SG. TT3 metabolism in patients with nephrotic syndrome and normal GFR compared with normal subjects. Am J physiol. 1991;260:E641-50.

Kapoor K, Saha A, Dubey NK. Subclinical no autoimmune hypothyroidism in children with steroid resistant nephritic syndrome. Clin Exp Nephrol. 2014;18(1):113-7.






Original Research Articles