An observational study of clinical profile of infants born to pregestational and gestational diabetic mothers

Sivakumar Elango, Murugesa Lakshmanan Sankarasubramanian, Balasubramanian Marimuthu


Background: Diabetes has now become a global pandemic because of sedentary lifestyle, urbanization, and increasing incidence of obesity and the prevalence is on the rise in developing nations like India. The objective of this study was to study the clinical profile and complications of neonates born to established diabetic mothers and gestational diabetic mothers on insulin.

Methods: Over a period of one year, all consecutive live born neonates born to diabetic mothers, both gestational and pregestational (known/established diabetic), on insulin were included in the study.

Results: The incidence of hypoglycemia in IPGDM was 2-fold higher (55%) than 25% in IGDM (25%) which was statistically significant (p = 0.009). Congenital anomalies were seen more in IPGDM (41.9%) compared to 18.2% in IGDM which was statistically significant (p=0.02).

Conclusions: Congenital anomalies mostly involving cardiovascular, renal system were seen significantly more in newborns born to mothers with established diabetes compared to infants of gestational diabetic mothers. Hypoglycemia was the most common complication followed by hypocalcemia and hyperbilirubinemia.


IDM, Gestational diabetes, Hypoglycaemia, Macrosomia

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Cloherty JP, Eichenwald EC, Stark AR. Diabetes mellitus. In: Manual on neonatal care. 7th ed. Philadelphia: Lippincott Williams and wilkins; 2013;2:11-22.

Nold JL, Georgieff MK. Infants of diabetic mothers Pediatr Clin N Am. 2004;51:619-37.

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2011;34:S62-9.

Jain A, Aggarwal R, Jeevasanker M, Agarwal R, Deorari AK, Paul VK. Hypoglycemia in the newborn. Indian J Pediatr. 2008;75(1):63-7.

Ranade, Merchant AY, Bajaj RH, Joshi RT. Infants of diabetic mothers: an analysis of 50 cases. Indian Pediatr. 1989;26(4):366-70.

Farooq MU, Ayaz A, Ali Bahoo L, Ahmad I. Maternal and neonatal outcomes in gestational diabetes mellitus. Int J Endocrinol Metab. 2007;3:109-15.

Mahmood CB, Kayes MI. Problems and immediate outcome of infant of diabetic mother. J Bangladesh Coll Phys Surg. 2008;26:67-72.

Firouzeh N, Mahdaviani. Comparision of morbidities between infants of pregestational and gestational diabetic mothers. MJIRI. 2004;18(1):13-9.

Akhlaghi F, Hamedi AB. Comparision of maternal and fetal/neonatal complications in gestational and pre-gestational diabetes mellitus. Acta Medica Iranica. 2005;43(4):263-7.