Survival and morbidities in very low birth weight (VLBW) infants in a tertiary care teaching hospital

Authors

  • Sweta Mukherjee Department of Pediatrics, Command Hospital, Kolkata, West Bengal, India
  • Subhash Chandra Shaw Department of Pediatrics, AFMC, Pune, Maharashtra, India
  • Amit Devgan Department of Pediatrics, Command Hospital, Kolkata, West Bengal, India
  • Ajay K Srivastava Department of Obstetrics and Gynecology, Command Hospital, Kolkata, West Bengal, India
  • Ashish Mallige Department of Pediatrics, Command Hospital, Kolkata, West Bengal, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20174751

Keywords:

Extremely low birth weight, Morbidities, Survival, Very low birth weight

Abstract

Background: Very low birth weight (VLBW) infants often need institutional advanced neonatal care. There is paucity of literature about the survival and morbidities of this very vulnerable group of preterm very low birth weight infants in tertiary care teaching hospitals. The aim of the study was to measure the outcome of VLBW infants in terms of survival and various short-term morbidities in a tertiary care teaching hospital.

Methods: This was a retrospective data analysis of all VLBW infants born in a tertiary care teaching hospital of eastern India, between 01 July 2014 and 31 December 2016. 35 VLBW infants were studied for the outcomes in terms of survival and morbidities like respiratory distress, apnoea of prematurity, intra ventricular haemorrhage, necrotizing enterocolitis, patent ductus arteriosus, retinopathy of prematurity and broncho pulmonary dysplasia.

Results: The overall survival rate of VLBW infants weighing >750 g (n=30) was 96.6% and <750 gm (n=5), was 40%. The commonest complications were respiratory distress (65.7%), neonatal hyperbilirubinemia (74.3%) and suspect early onset sepsis (51.4%) based on maternal risk factors.

Conclusions: The majority of VLBW infants above 750 g at birth or ≥ 26 weeks POG, survived in a tertiary care teaching hospital.

 

References

PHFI, AIIMS, and SC- State of India's Newborns (SOIN) 2014- a report. (Eds). Zodpey S and Paul VK. Public Health Foundation of India. Available at http://www.phfi .org/images/pdf/soin_report.pdf

March of Dimes, PMNCH, Save the Children, WHO. Born Too Soon: The Global Action Report on Preterm Birth. Eds CP Howson, MV Kinney, JE Lawn. World Health Organization. Geneva, 2012

Blencowe H, Cousens S, Oestergaard M, Chou D, Moller AB, et al. National, regional and worldwide estimates of preterm birth rates in the year 2010 with time trends for selected countries since 1990: a systematic analysis and implications. Lancet. 2012 Jun 9;379(9832):2162-72.

Saugstad OD, Aune D. Optimal oxygenation of extremely low birth weight infants: A meta-analysis and systematic review of the oxygen saturation target studies. Neonatology. 2014;105:55-63.

Lubchenco L, Hansman C, Dressler M, Boyd E. Intrauterine growth as estimated from live born birth weight data at 24 to 42 weeks of gestation. Pediatrics. 1963;32:793-800.

Ballard JL, Khoury JC, Wedig K, Wang L, Eilers-Walsman BL, Lipp R. New Ballard Score, expanded to include extremely premature infants. J Pediatr. 1991 Sep;119(3):417-23.

Volpe JJ. Intraventricular hemorrhage and brain injury in the premature infant. Neuropathology and pathogenesis. Clin Perinatol. 1989;16:361-86.

Walsh MC, Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am. 1986;33:179-201.

The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol. 2005;123:991-9.

Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163:1723-9.

Narayan S, Aggarwal R, Upadhyay A, Deorari AK, Singh M, Paul VK. Survival and morbidity in extremely low birth weight (ELBW) infants. Indian Pediatrics. 2003;40:130-5.

Tagare A, Chaudhari S, Kadam S, Vaidya U, Pandit A, Sayyad MG. Mortality and morbidity in extremely low birth weight (ELBW) infants in a neonatal intensive care unit. Indian J Pediatr. 2013 Jan;80(1):16-20.

Mukhopadhyay K, Louis D, Murki S, Mahajan R, Dogra MR, Kumar P. Survival and morbidity among two cohorts of extremely low birth weight neonates from a tertiary hospital in Northern India. Indian Pediatr. 2013;50:1047-1050.

Shim JW, Jin HS, Bae CW. Changes in Survival Rate for Very-Low-Birth-Weight Infants in Korea: Comparison with Other Countries. J Korean Med Sci. 2015;30:S25-34

Horbar JD, Carpenter JH, Badger GJ, Kenny MJ, Soll RF, Morrow KA et al. Mortality and neonatal morbidity among infants 501 to 1500 grams from 2000 to 2009. Pediatrics 2012;129:1019-26.

The Canadian Neonatal Network TM. Available at http://www.canadianneonatalnetwork.org/portal.

European Neonatal Network. EuroNeoNet Available at http://www.euroneonet.eu/paginas/publicas/euroneo/euroNeoNet/index.html

Numerato D, Fattore G, Tediosi F, Zanini R, Peltola M, Banks H, et al. Mortality and length of stay of very low birth weight and very preterm infants: A Euro HOPE study. PLoS One. 2015;10(6):e0131685.

Roberts D, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD004454.

Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993–2012. JAMA. 2015 September 8;314(10):1039-51.

Ballot DE, Chirwa TF, Cooper PA. Determinants of survival in very low birth weight neonates in a public sector hospital in Johannesburg. BMC Pediatrics. 2010;10:30.

Downloads

Published

2017-10-24

Issue

Section

Original Research Articles