Case report on neonatal renal failure due to prenatal exposure of Telmisartan

Authors

  • Poonam Agrawal Department of Paediatrics, SVPPGIP and SCB Medical College and Hospital, Cuttack, Odisha, India
  • Manas Upadhyay Department of Paediatrics, SVPPGIP and SCB Medical College and Hospital, Cuttack, Odisha, India
  • Rajlaxmi Upadhyay Department of Pharmacology, SCB Medical College and Hospital, Cuttack, Odisha, India
  • Saroj kumar Satpathy Department of Paediatrics, SVPPGIP and SCB Medical College and Hospital, Cuttack, Odisha, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20172707

Keywords:

Acute renal failure, Telmisartan, oligohydramnios

Abstract

Telmisartan is an antihypertensive medication, which acts as an angiotensin II receptor blocker, and has an inhibitory effect on the renin-angiotensin system. Angiotensin receptor blockers(ARBs) are contraindicated in pregnancy (category D); adverse effects have been reported in both animal and human pregnancies, but still pregnant mothers do come with this medication with consequent neonatal adverse complications. We report 2 such cases of adverse neonatal outcomes in hypertensive mothers exposed to Telmisartan during pregnancy.

References

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Berkane N, Carlier P, Verstraete L, Mathieu E, Heim N, Uzan S. Fetal toxicity of valsartan and possible reversible adverse side effects. Birth Defects Res A Clin Mol Teratol. 2004;70(8):547-9.

Celentano C, Prefumo F, di Vera E, Iannicco A, Gallo DP, Liberati M. Reversible acute fetal renal failure due to maternal exposure to angiotensin receptor blocker. Pediatr Nephrol. 2008;23(2):333-4.

Oppermann M, Padberg S, Kayser A, Weber-Schoendorfer C, Schaefer C. Angiotensin-II receptor 1 antagonist fetopathy--risk assessment, critical time period and vena cava thrombosis as a possible new feature. Brit J Clinical Pharmacol. 2013;75(3):822-30.

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Published

2017-06-21

Issue

Section

Case Reports