Study of thyroid profile in malnourished children (6 months - 5 years) admitted in the nutritional rehabilitation centre and paediatric ward NSCB Medical College Jabalpur, India

Authors

  • Monica Lazarus Department of Pediatrics, NSCB Medical College and Hospital, Jabalpur, Madhya Pradesh, India
  • Alok Kumar Kashyap Department of Pediatrics, NSCB Medical College and Hospital, Jabalpur, Madhya Pradesh, India
  • Rahul Borkar Department of Pediatrics, NSCB Medical College and Hospital, Jabalpur, Madhya Pradesh, India
  • Manish Ajmariya Department of Pediatrics, NSCB Medical College and Hospital, Jabalpur, Madhya Pradesh, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20181545

Keywords:

Moderate acute malnutrition, Protein energy malnutrition, Severely acute malnutrition, Thyroid stimulating hormone, Triiodothyronine, Thyroxine

Abstract

Background: Globally, PEM continues to be a major health problem in developing countries and the most important risk factor for illnesses and death especially among young children. The research was conducted to study the effect of thyroid profile in malnourished children (6 month-5 years) admitted in tertiary care center in Central India.

Methods: A cross sectional hospital based observational study was carried out in tertiary care hospital NSCB MCH Jabalpur. 80 malnourished children were included in the study. The cases were categorized into moderate and severe malnutrition as per WHO classification.  Detailed clinical assessment of nutritional status followed by anthropometric measurement (weight for height) was recorded in predesigned proforma. Triiodothyronine (T3), Thyroxine (T4), thyroid stimulating hormone (TSH), serum total protein and serum albumin were estimated. The parameters were compared among SAM and MAM groups using appropriate tool.

Results: Mean serum protein, serum albumin, T3, T4 were significantly low in SAM group, when compared to the MAM group (p <0.001). while level of TSH was not found significant among SAM and MAM groups.

Conclusions: Malnutrition is associated with decrease level of thyroid hormone levels and were positively correlated with serum total protein and albumin levels. The decrease level of thyroid hormone may have a contributory role in retarded growth and development.

References

Muller O, Krawinkel M. Malnutrition and health in developing countries. CMAJ. 2005;173(3):279-86.

Faruque ASG, Ahmed AMS, Ahmed T, Islam MM, Hossain MI, Roy SK, et al. Nutrition: basis for healthy children and mothers in Bangladesh. J Health Popul Nutr. 2008;26(3):325-39.

UNICEF. Committing to child survival: a promise renewed- progress report. 2013. Available at https://www.unicef.org/media/files/UNICEF_2013_A_Promise_Renewed_Second_Progress_Report_Full_Report.pdf

UNICEF. Tracking Progress on child and maternal nutrition: a survival and development priority. New York: UNICEF. 2009. Available at https://www.unicef.org/publications/files/Tracking_Progress_on_Child_and_Maternal_Nutrition_EN_110309.pdf

International Institute for Population Sciences (IIPS) and Macro International. National Family Health Survey (NFHS-3), 2005-06: India. 2007;1. Available at http://rchiips.org/nfhs/NFHS-3%20Data/VOL-1/India_volume_I_corrected_17oct08.pdf

Abrol P, Verma A, Hooda HS. Thyroid hormone status in protein energy malnutrition in Indian children. Indian J Clin Biochem. 2001;16(2):221-3.

Mishra SK, Bastola SP, Jha B. Biochemical nutritional indicators in children with protein energy malnutrition attending Kanti Children Hospital, Kathmandu, Nepal. Kathmandu University Med J. 2009;7(26):129-34.

Robert B, Baron MD. Nutritional Disorders. In: Stephen JM, Maxine AP, editors. Current Medical Diagnosis and Treatment (CMDT). 48th edn: New York: McGraw Hill; 2009:1107-25.

Stirling GA. Thyroid status in malnutrition. Arch Dis Child. 1962;37:99-102.

Hatemi N, Haktan M, Genca E, Cuma T. Thyroid function in protein energy malnutrition Turk. J Peditr. 1982;24:2934.

Turkay S, Kus S, Gokalp A, Baskin E, Onal A. Effects of protein energy malnutrition on circulating thyroid hormones. Ind Pediatr. 1995;32:193-7.

Yadav SS, Yadav ST, Mishra P, Mittal A, Kumar R, Singh J. An epidemiological study of malnutrition among under five children of rural and urban Haryana. J Clin Diag Res. 2016;10(2):LC07-LC10.

Chakraborty S, Gupta SB, Chaturvedi B, Chakraborty SK. A study of protein energy malnutrition (PEM) in children (0 to 6 year) in a rural population of Jhansi district (UP). Indian J Comm Med. 2006;31(4):291.

Mehta S. Thyroid hormone status in children with severe acute malnutrition. EJPMR. 2017;4(4):592-4.

Dhanjal GS, Singh M. Thyroid hormone status in children with protein energy malnutrition a hospital-based case control study. Int J Contemp Pediatr. 2017;4(2):351-5.

Kumar S, Nandkarni J, Dwivedi R. Thyroid hormone status in malnourished children. Indian Pediatr. 2009;46:263-4.

Khatum FUH, Khan MR, Ara F, Ahamed K, Choudhury SA. Study of thyroid functions in protein energy malnutrition. Bangladesh Med Res Counc Bull. 1982;8(2):68-71.

Onuora C, Maharajan G, Singh A, Etta KM. Thyroid status in various degrees of protein-calorie malnutrition in children. Clin Endocrinol 1983;18:87-93.

Valinjkar SK, Sutay NR, Prachi, Vikas. Thyroid status and serum protein levels in severe and moderate acute malnourished children. JMSCR. 2016;4(1):5059-67.

Downloads

Published

2018-04-20

Issue

Section

Original Research Articles